New, real-world research confirms that the blockbuster weight-loss drugs that millions of Americans have been taking to shed pounds can trigger stomach paralysis in some patients.
do work and should be used for the right reason, we just want to caution everyone that if you do decide to start this, be prepared that you have a 30 percent chance that you may have GI side effects, and then the drug may have to be discontinued,” Dr. Prateek Sharma, a professor of medicine at the University of Kansas School of Medicine who conducted one of the studies, toldHis research was one of two reports presented Saturday at the Digestive Disease Week 2024 in Washington, D.C.
While the overall risk to any one patient remains small, the difference amounted to a 52% increased risk of being diagnosed with stomach paralysis while on a GLP-1 medication. Compared with those who were not taking a GLP-1 medication, those who did were about 66% more likely to be diagnosed with gastroparesis.
“You need hundreds of thousands of patients to come up with these conclusions, but that's why I think these database studies are much more important there,” Sharma said.“It's very important, if you're going to study the problem with gastric emptying, you have to look at the gastric emptying of solids, not of liquids,” he explained, because liquids pass through the stomach faster than solids do.
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