In the latest update of Vertex's VX-880, three patients at high hypoglycemia risk achieved A1c | 7% with no severe hypoglycemia episodes and were insulin independent at 1 year.
Of a total 17 patients who received a full dose of Vertex Pharmaceuticals, Inc.
Asked to contrast the potential of stem cell–derived islet therapy with that of diabetes technology, endocrinologist David T.
The open-label phase 1/2 of the FORWARD study enrolled 17 people with type 1 diabetes aged 18-65 years who had impaired hypoglycemic awareness and had experienced two or more severe hypoglycemic episodes in the year prior to screening. The first two patients received a half dose of VX-880 with sequential dosing, the next six full-dose with sequential dosing, and the subsequent 10 full-dose with concurrent dosing.
Of 10 participants who completed the day 180 visit, seven were no longer using exogenous insulin, two had about a 70% reduction in their total daily insulin dose and may be able to stop insulin in the future, and one had about a 24% insulin dose reduction, Witkowski reported. In 2022, ViaCyte, a company subsequently acquired by Vertex, initiated an open-label study of gene-edited pancreatic progenitor cells, in partnership with CRISPR Therapeutics' gene editing technology. The first of a planned 10 patients received the cells, but no data have been released.
Diabetes Mellitus Type I Type 1 Diabetes Type 1 DM T1DM T1D Transplantation Of Stem Cells Transplantation Of Hematopoietic Stem Cells Hematopoietic Stem Cell Transplant Stem Cell Transplantation Stem Cell Therapy Stem Cell Haematopoietic Stem Cell Transplant HSCT Hematopoietic Stem Cell Transplantation (HSCT) Haematopoietic Stem Cell Transplantation (HSCT)
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