Douglas S. Paauw, MD, details some common misunderstandings about statins including their effect on the liver, on muscles, and in older patients.
Professor of Medicine, Division of General Internal Medicine; Third-Year Medical Student Clerkship Director, University of Washington, Seattle; Member, editorial advisory board, Internal Medicine News. After discharge, she had symptoms of dizziness and recurrent chest pain and her first thought was to stop the statin because she believed that her symptoms were statin-related side effects. I will cover a few areas where I think that there are some misunderstandings about statins.
Herrett and colleagues performed an extensive series of n-of-1 trials involving 200 patients who had stopped or were considering stopping statins because of muscle symptoms.Participants received either 2-month blocks of atorvastatin 20 mg or 2-month blocks of placebo, six times. They rated their muscle symptoms on a visual analogue scale at the end of each block. There was no difference in muscle symptom scores between the statin and placebo periods.
Wood and colleagues took it a step further when they planned an n-of-1 trial that included statin, placebo, and no treatment.Each participant received four bottles of atorvastatin 20 mg, four bottles of placebo, and four empty bottles. Each month they used treatment from the bottles based on a random sequence and reported daily symptom scores. The mean symptom intensity score was 8.0 during no-tablet months, 15.
Lipid Management Statin Lipid Lowering Drugs Biliary Disease Gallbladder Disease Myalgia Muscle Pain Nonalcoholic Fatty Liver Disease NAFLD Non-Alcoholic Fatty Liver Disease Non-Alcoholic Fatty Liver Disease (NAFLD) Liver Aminotransferase Ast Liver Enzymes Liver Studies Alt Transaminase Muscles Pain Management Fatty Liver Steatorrhoeic Hepatosis Steatosis Hepatis
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