Science, Space and Technology News 2024
Stanford researchers have found that blocking the kynurenine pathway in the brain can reverse the metabolic disruptions caused by Alzheimer’s disease, improving cognitive functions in mice. Credit: SciTechDaily.comdisease to the disruption of brain metabolism via the kynurenine pathway, which is affected by amyloid plaque and tau proteins.
“We were surprised that these metabolic improvements were so effective at not just preserving healthy synapses, but in actuallybehavior. The mice performed better in cognitive and memory tests when we gave them drugs that block the kynurenine pathway,” said senior author, Katrin Andreasson, a neurologist at the Stanford School of Medicine and member of the Wu Tsai Neurosciences Institute.
In those tests, in which mice with Alzheimer’s Disease must navigate an obstacle course before and after drug intervention, Andreasson and team found that the drugs improved hippocampal glucose metabolism, corrected deficient astrocytic performance, and improved the mice’s spatial memory.“We also can’t overlook the fact that we saw this improvement in brain plasticity in mice with both amyloid and tau mice models.
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