Stanford University President Marc Tessier-Lavigne’s research on guidance cues for growing nerve fibers has drawn new scrutiny.
publications now under scrutiny, produced when he was at the University of California, San Francisco , came after his initial landmark netrin discoveries., an online forum where scientists identify and discuss possible problems in published research, often anonymously. Some posts suggested various Western blots, which document a protein’s presence in a sample, were repeated in more than one figure or altered.
Elisabeth Bik, a specialist in spotting manipulated images, reexamined the three papers and other Tessier-Lavigne publications noted in PubPeer at the request of the. She calls some image changes “beautification” that did not affect the papers’ conclusions but describes others as “more serious.”it discussed concerns about the papers with Tessier-Lavigne when he was under consideration for university president in 2015.
Tessier-Lavigne’s troubles are a warning to investigators everywhere to keep an eye on how lab members edit images of data, some say. “In this day and age, it’s very easy to manipulate digital images. There’s a lot of trust built into science and trust can be abused,” says neurobiologist Tim Kennedy of McGill University. “On the flip side, science is a self-correcting enterprise.”
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