Combining sorafenib with TACE extended overall survival in patients with recurrent intermediate-stage hepatocellular carcinoma compared with TACE alone.
intermediate-stage HCC has a poor prognosis, and TACE alone has yielded"unsatisfactory survival benefits," the study authors explained. Retrospective studies suggest that combining sorafenib and TACE may be a better therapeutic option.
Sorafenib, an inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptors, may have a synergistic effect alongside TACE after hepatectomy in patients with positive microvascular invasion. To investigate further, 162 patients with recurrent intermediate-stage HCC and positive microvascular invasion were randomly allocated to sorafenib plus TACE or TACE alone.Median overall survival was significantly longer with sorafenib plus TACE than with TACE alone and increased aspartate aminotransferase .
HCC - Hepatocellular Carcinoma Liver Cancer HCC Hepatocellular Cancer Cancer Of The Liver Liver Carcinoma Carcinoma Of The Liver Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Aminotransferase Ast Liver Enzymes Liver Studies Alt Transaminase Hospitals Platelet Growth Factor Platelet-Derived Growth Factor Hepatitis B HBV - Hepatitis B Virus HBV
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