Some people with COVID shed nearly 60 times as much virus as others

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Some people with COVID shed nearly 60 times as much virus as others
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Daily testing at a university has revealed huge discrepancies in the infectiousness of people who test positive for COVID

Testing shows that people who shed the most virus release nearly 60 times as much SARS-CoV-2 as those who shed the least. Credit: Indranil Aditya/NurPhoto via Getty

Daily testing at a university has revealed huge discrepancies in the infectiousness of people who test positive for SARS-CoV-2.

The researchers found substantial differences in the number of days for which the participants shed virus capable of infection: one participant excreted viable virus from their nose for nine days, whereas nine participants showed no detectable levels of infectious virus throughout the testing period. Modelling estimated that the most-infectious people shed more than 57 times more virus over the course of infection than did the least-infectious individuals.

Levels of viral RNA peaked several days earlier in saliva than in nasal samples, and became undetectable two to three weeks later.

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