In a group of men followed for a median of 15 years, mortality from prostate cancer was similar whether they received radiation, surgery or active monitoring.
As part of the study, which was funded by the British government, more than 80,000 men between 50 and 69 were screened for prostate cancer between 1999 and 2009. More than 2,600 were diagnosed with the disease, and 1,643 were enrolled in the trial.The men were at low- or intermediate-risk from their disease, and the authors stressed that their findings do not apply to men at high risk. “High-risk patients need quick and aggressive treatments,” Hamdy said.
The researchers split the men in the cohort into three groups who were monitored over time or treated with radiotherapy or prostatectomy, a surgical procedure to remove all or parts of a patient’s prostate. The goal was to measure and compare the effectiveness of each treatment. At a median of 15 years post-diagnosis, the men were given a follow-up to see how they were faring. Fewer than 3 percent had died of prostate cancer, and the odds were similar for each treatment group. For example, 3.1 percent of the deaths came among men in the active-monitoring group, while 2.9 percent were among men who received radiotherapy.
Because prostate cancers typically progress slowly, even if the cancer evolves more quickly under active monitoring, the study’s finding suggests that the long-term deleterious effects of harsh treatment may not be worth it.
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