Clinicians could consider beta blockers instead of calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers to help reduce risk.
SAN DIEGO — In patients with metabolic dysfunction–associated steatotic liver disease , hypertension, and cirrhosis, certain antihypertensive medications may lead to increased risks for hepatocellular carcinoma , according to new research.
However, previous studies have suggested a possible link between these medications and cancer development, “especially CCBs and breast and lung cancer,” said Elhariri, who presented the findings atIn a case-control study, Elhariri and colleagues analyzed antihypertensive medication use among patients with MASLD-induced HCC, as defined by histology or radiology based on the Liver Imaging Reporting & Data System, and control patients with MASLD but without HCC.
After adjusting for age, sex, BMI, Hispanic ethnicity, and use of other medications, patients taking CCBs had an increased HCC risk compared with those not taking CCBs. Patients taking ACE inhibitors or ARBs also had an increased HCC risk compared with those not taking ACE inhibitors or ARBs. “We need to carefully review blood pressure medications in patients with MASLD and cirrhosis,” he said. CCBs, ACE inhibitors, and ARBs can be replaced with beta blockers, “which have been shown to reduce progression of cirrhosis-related complications.
HCC - Hepatocellular Carcinoma Liver Cancer HCC Hepatocellular Cancer Cancer Of The Liver Liver Carcinoma Carcinoma Of The Liver Biliary Disease Gallbladder Disease Hypertension Nonalcoholic Fatty Liver Disease NAFLD Non-Alcoholic Fatty Liver Disease
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