It might be time to tuck in for the night.
Getting enough sleep helps your body clear the brain of harmful proteins related to Alzheimer's disease.According to the team's research, immune cells known as macrophages, which function to rid the body of unwanted material, help clear harmful AB42 from the brain during a process called phagocytosis. Previous studies conducted by Hurley and her team found that the levels of macrophage RNA and proteins rise and fall along with the body's circadian rhythm.
The latest experiment tested the changes brought on by the circadian rhythm and how they related to the cell surface structures, discovering that the amount of AB42 that the healthy macrophages can clear follows the same cycle—meaning sleep plays a factor in optimizing the process. By comparison, other immune cells that aren't regulated by the body's internal clock didn't share this pattern.
"What's clear is that this is all timed by the circadian clock," Hurley explains."When there's a lot of these cell surface proteoglycans, the macrophages don't ingest the AB42. We're not certain why that would be, but there is definitely a relationship. In theory, if we could boost that rhythm, perhaps we could increase the clearance of AB42 and prevent damage to the brain," she concludes.
Other studies have found that getting six or fewer hours of sleep each night could increase your dementia risk.While getting enough sleep overall is essential, another study published in April 2021 in the scientific journal
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