Dropping 5-FU bolus from multidrug regimens is associated with lower rates of cytopenia in gastrointestinal cancers without affecting survival.
bolus from multidrug regimens in patients with advanced gastrointestinal cancers reduces toxicities, such as cytopenia, and does not affect overall survival.recommend 5-FU multidrug regimens, such as FOLFOX, FOLFIRI, and FOLFIRINOX, which involve a short intravenous bolus of 5-FU followed by a prolonged infusion. However, 20%-40% of oncologists reported skipping 5-FU bolus.
To evaluate the impact of 5-FU bolus on overall survival and toxicity, researchers assessed 11,765 patients with advanced gastrointestinal cancers who received frontline treatment with FOLFOX , FOLFIRI , or FOLFIRINOX regimens. The median age was 63 years, 64.2% were White, and 59.6% were men; 8670 patients had colorectal, 1481 had gastroesophageal, and 1614 had pancreatic cancers.
Of all participants, 10,148 received 5-FU bolus on the first day of treatment. The bolus was administered to 90.4% of patients who received FOLFOX, 89.2% of those who received FOLFIRI, and 61.6% of those who received FOLFIRINOX.Initial unadjusted analyses indicated that patients receiving the 5-FU bolus had longer overall survival than those who did not .
This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Noncolorectal Gi Cancer Gastrointestinal Malignancy Gi Malignancy Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Gastric Cancer Malignant Stomach Neoplasm Stomach Cancer Gastric Carcinoma Malignant Pancreatic Neoplasm Pancreatic Cancer Cancer Of The Pancreas Tolerance Thrombocytopenia Neutropenia
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