Single dose of aged mouse blood in young mice causes senescence Aging Blood senescence NatMetabolism BuckInstitute UniversityKorea UCBerkeley UCSF BerkeleyLab
By Dr. Priyom Bose, Ph.D.Aug 18 2022Reviewed by Benedette Cuffari, M.Sc. When cells are exposed to stress and damage, cellular senescence occurs. This phenomenon increases with aging.
Heterochronic parabiosis involves the surgical joining of young and old mice by sharing both blood and organs, as well as their environments. Study findings Cellular senescence occurs in response to extrinsic and intrinsic signals. Some of the factors that trigger senescence include genomic damage, metabolic imbalances, mitochondrial dysfunction, and mitogenic signals induced by activated oncogenes.
This comparison revealed that serum from old mice exhibited enhanced expressions of the senescence up-regulated genes Cdkn2a, and Cdkn1a, as well as SASP factors like Il6 and Mmp3 as compared to younger mice. This finding was determined using a cytokine array. Heterochronic blood exchanges between young and old mice were performed, with a control setup using isochronic exchanges. Bioluminescence of the p16-3MR reporter was tracked to assess if old blood could systematically induce senescence in young p16-3MR mice.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Eating grapes may reduce the risk of fatty liver diseaseEating grapes may reduce the risk of fatty liver disease FattyLiver Liver LiverDisease grapes metabolicdiseases RNAsequencing nutrigenomics longislandu MSKCancerCenter WNEUniversity Foods_MDPI
Read more »
Calls for 'proper' compensation after NHS infected blood scandalVictims of the infected blood scandal say they remain angry despite £100,000 compensation payments.
Read more »
Infected blood victims to be offered £100,000 in government compensationKit Malthouse MP says he is pleased that payments are now being offered to victims of the infected blood scandal but concedes that money can never compensate fully. Read more about the scandal here:
Read more »
Contaminated blood scandal ‘tragedy’, says former health minister“It’s a tragedy and a scandal.” Lord Owen, a former health minister and a long-time campaigner on behalf of contaminated blood victims, tells cathynewman “there are huge lessons to learn in the way the department was run”.
Read more »