Single-cell mapping of combinatorial target antigens for CAR switches using logic gates
Extended Data Fig. 9 Additional single-cell epitope analysis results for EPCAM and CD24 in ovarian cancer., Distribution of EPCAM and CD24 protein expression levels broken down by annotated cell type. Log2 fold changes comparing CITE-seq ADT signals from targeting antibodies versus isotype controls were computed and are displayed in each cell type., Clustering and cell-type mapping of tumor and tumor-resident normal cells based on the CITE-seq transcriptome.
, Distribution of protein expression levels broken down by annotated cell type. Log2 fold changes comparing CITE-seq ADT signals from targeting antibodies versus isotype controls were computed and are displayed for each protein in each cell type., Cell-by-cell protein expression patterns in the tumor and tumor-resident normal cells for CEACAM5 versus EPCAM, CEACAM5 versus CA4, CEACAM5 versus CPM, and CEACAM5 versus VSIG2.
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