Researchers at the Centre for Genomic Regulation and Vall d'Hebron Institute of Oncology have shown that the simultaneous inhibition of two different proteins may represent a new strategy for tackling triple-negative breast cancer, the most aggressive and drug-resistant form of breast cancer.
Reviewed by Lily Ramsey, LLMNov 8 2023 The findings are published today in the journal EMBO Molecular Medicine.
The enzyme LOXL2 has recently been shown to drive the growth of triple-negative breast cancer. A team led by Dr. Sara Sdelci at the Centre for Genomic Regulation and Dr. Sandra Peiró, together with researchers in the Upper GI Cancer Translational Research Group at the Vall d'Hebron Institute of Oncology, carried out various analyses to assess the enzyme's suitability as a biomarker that can predict treatment outcome.
Our deep dive into how triple-negative breast cancer cells grow at the molecular level have revealed a new mechanism which can be exploited for treatment purposes. It is exciting because a double strike strategy that targets both proteins could be combined with other treatments and transform triple-negative breast cancer from a disease with a very poor prognosis into one that is manageable."
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