Researchers have uncovered vascular “fingerprints” in the eye that are strongly associated with increased risk for stroke.
Researchers have identified novel retinal vascular signatures that are significantly associated with the risk for a first stroke. When combined with age and sex, these retinal “fingerprints” predicted stroke risk as well as established traditional risk factors.
In the current study, researchers used an advanced artificial intelligence algorithm — retina-based microvascular health assessment system — to analyze 118 retinal vascular parameters using fundus photographs from 45,161 participants in the UK Biobank cohort. More than half were related to density, highlighting the unique role of retinal density in assessing incident stroke risk, reported Mayinuer Yusufu, MBBS, with the Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia, and colleagues.
Specifically, one SD decrease in arterial bifurcation density increased risk by 10.7%, and one SD decrease in branching density in arteries, veins, and vessels in the macula increased risk by 9.9%-12.1%. Each SD decrease in the identified parameters of vessel area density and vessel skeleton density increased the risk for stroke by 11.6%-19.0%.
For the eight identified retinal complexity measures and the one identified tortuosity measure, each SD decrease was linked to increased stroke risk, ranging from 10.4$ to 19.5%.
Cerebrovascular Accident CVA Cerebrovascular Accident (CVA) Stroke Risk Eye Vision Screening Eye Examination Arteries Scan Fundus Vision Care And Maintenance Macula Nebraska Retina Low Hdl Cholesterol Hypoalphalipoproteinemia Low High-Density Lipoprotein Cholesterol Hypoalphalipoproteinaemia CV Risk Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors
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