Limited data and lack of head-to-head studies make comparisons tricky
For cardiologist Eric Topol, this week’s vaccine news presented a personal dilemma. Topol, who directs the Scripps Research Translational Institute and is a popular commenter on COVID-19 research, had hoped to get an updated COVID-19 vaccine from Novavax, rather than a messenger RNA shot from Pfizer or Moderna. Novavax relies on an older, protein-based approach that has shown long-lasting effects against other pathogens, and Topol wondered whether it might produce more durable protection.
Whereas mRNA vaccines carry instructions for making a SARS-CoV-2 protein, Novavax directly delivers a fragment of that viral spike protein with an adjuvant for boosting immune response. Such protein subunit vaccines have yielded durable protection against various pathogens including hepatitis B and shingles, along with some respiratory ailments such as pneumonia.
At the University of Maryland School of Medicine, infectious disease specialist and vaccine researcher Kirsten Lyke is leading a mix-and-match study in which 67 of the roughly 830 participants got the original Novavax vaccine as a first booster, having received Pfizer, Moderna, or Johnson & Johnson as their primary vaccination.
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