Abbreviated azacitidine plus venetoclax course had comparable efficacy to standard hypomethylating agent plus venetoclax in older patients with acute myeloid leukemia.
CHICAGO — An abbreviated course of azacitidine for 7 days plus venetoclax for 7 days showed similar efficacy to a standard hypomethylating agent plus venetoclax doublets in older and unfit patients with newly diagnosed acute myeloid leukemia in a multicenter retrospective analysis.
The median number of cycles to first response was one in both groups, but 42% of responders in the 7+7 group required more than one cycle to achieve their first response, compared with just 1% of those in the standard therapy group, he noted, adding that the median number of cycles to achieve best response was two in the 7+7 group and one in the standard therapy group.
Of note, fewer patients in the 7+7 group required platelet transfusions during cycle 1 and the cycle 1 rates of neutropenic fever and red cell transfusion requirements were similar in the two treatment groups, Dr Bazinet said. These findings are limited by the retrospective study design and by small patient numbers in many subgroups, he said.
Acute Leukaemia Toxicology Toxicity Poisoning Toxins Platelet Transfusion Plateletpheresis Thrombapheresis Thrombocytapheresis Acute Myeloblastic Leukemia Acute Myeloid Leukemia Acute Myelocytic Leukemia Acute Myelogenous Leukemia Aml Acute Granulocytic Leukemia
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