Short breaks with light-intensity walks to interrupt long sitting hours improved postprandial vascular inflammatory biomarker levels in people with type 1 diabetes.
Breaking up long sitting periods with short, frequent bouts of light-intensity walks may reduce the increased levels of postprandial vascular inflammatory biomarkers seen in people withA sedentary lifestyle, prevalent in patients with T1D , increases the risk for cardiovascular complications, but it is unclear whether reversing sedentary behavior modulates the thromboinflammatory milieu.
The SIT-LESS study, a randomized crossover trial, included 32 people with T1D who were on a stableregimen and were classified as"inactive" by international guidelines on physical activity . The participants completed two 7-hour laboratory visits separated by a gap of ≥ 7 days and either remained seated for the entire period in a reclining chair or interrupted sitting every 30 minutes by self-paced, of 3-minute light walks beginning 1 hour after each meal.
Meals, insulin regimen, and step counts were recorded 48 hours before and after the first laboratory visit, and plasma levels of interleukin –1 beta, tumor necrosis factor alpha,Prolonged sitting led to postprandial increase in TNF-alpha, IL-1 beta, PAI-1, and fibrinogen levels over time.
Diabetes Mellitus Type I Type 1 Diabetes Type 1 DM T1DM T1D Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity Insulin Resistance Exercise Physical Activity Metabolism Metabolic UK Site Content United Kingdom Site Content United Kingdom UK Clinical Guidelines Guidelines Interleukins Plasma Tumor
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