Though many patients are advised to stop SGLT2s at hospital admission, new results from the ENDORSE-HF trial suggest that there could be a good reason to continue treatment.
Adding dapagliflozin to diuretic therapy in acute heart failure patients"also increases natriuresis and improves the ejection fraction," said study presenter Ioan Radu Lala, MD, PhD, a cardiologist at Arad County Emergency Clinical Hospital, Arad, Romania, at the Heart Failure Association of the European Society of Cardiology 2024.
The addition of the SGLT2 inhibitor allows"rapid, efficient decongestion, which facilitates the early introduction of the four pillars of heart failure therapies," Lala said, namely SGLT2 inhibitors, angiotensin receptor–neprilysin inhibitors, beta-blockers, and mineralocorticoid receptor antagonists.
ENDORSE-HF also saw a reduction in diuretic doses with the addition of an SGLT2 inhibitor, but the result was not statistically significant. Lala said in an interview that this could be because they did not specify a protocol for IV diuretic use, instead relying on the"pure clinical judgement" of the participating physicians, who were perhaps used to giving higher doses to rapidly decongest the patient.
Hypertension Acute Heart Failure Acute HF Diuretics Heart SGLT2 Inhibitors Sodium-Glucose Transporter-2 Inhibitors Sodium-Glucose Co-Transporter-2 Inhibitors Sodium-Glucose Cotransporter-2 Inhibitors Cardiovascular Imaging Cardiac Imaging CV Imaging Hospitals Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Patient Safety Prognosis
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