Seroprevalence study demonstrates vaccination could boost impaired humoral immunity against Omicron BQ.1.1 subvariant medrxivpreprint UniCologne SARSCoV2 COVID19 Coronavirus Omicron Subvariant Vaccination
By Neha MathurJan 5 2023Reviewed by Aimee Molineux In a recent study posted to the medRxiv* server, researchers conducted a multicenter, cross-sectional seroprevalence study in emergency departments of five hospitals in North Rhine-Westphalia, Germany, between August and September 2022. They assessed point seroprevalence and neutralization activity against Wu01, BA.4/5, and BQ.1.1.
About the study In the present multicenter study, researchers first collected blood serum samples of all 1411 participants. They used enzyme-linked immunosorbent assay and chemiluminescence immunoassay to determine spike and nucleocapsid immunoglobulin G levels against Wu01, BA.4, BA.5, and BQ.1.1. Additionally, they measured serum neutralization against these three variants using pseudovirus neutralization assays.
Study findings Drug Discovery eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The average age of study enrollees was 53 years, and 48.5% and 51.3% were females and males, respectively. Over 64% of the participants had pre-existing health conditions, such as cardiovascular and neoplastic diseases, and 13.6% reported drug immunosuppression. Based on age stratification, 67.7% of study participants were vaccinated, with 94.
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