The effects in an obese population without diabetes and low rates of kidney disease suggest a 'potential role in the primary prevention of CKD.'
in this patient population in the absence of diabetes," lead author Helen M. Colhoun, MD, of the Institute of Genetics and Cancer, The University of Edinburgh, Scotland, UK,) trial, which evaluated cardiovascular outcomes of semaglutide treatment among 17,604 adults with pre-existing cardiovascular disease who were overweight or obese — but did not have diabetes.
The primary endpoint for the analysis was a nephropathy composite of time from randomization to the first occurrence of death from kidney causes; initiation of chronic kidney replacement therapy; onset of persistent estimated glomerular filtration rate < 15 mL/min/1.73 m; persistent ≥ 50% reduction in eGFR compared with baseline; or onset of persistent macroalbuminuria.
"We were hopeful that there would be similar benefits as those observed in the diabetes studies, but there are differences in kidney disease among those with and without type 2 diabetes, so we weren't sure," Colhoun toldalso published this month that showed a mean 10.2% reduction in weight sustained for up to 4 years, a key question is whether the kidney benefits are a direct result of weight loss — or the drug mechanism or something else.
"So, I would say the data suggest there is some component of this that is attributable to weight, but we certainly can't attribute all of the to weight change."
Obese Chronic Renal Failure Chronic Kidney Failure CKD - Chronic Kidney Disease Chronic Kidney Disease CKD Renal Failure Renal Insufficiency Kidney Insufficiency Kidney Failure Renal Impairment Diabetes Mellitus Type 2 Diabetes Mellitus Type Ii Type 2 Diabetes Type 2 DM T2DM T2D Kidneys Renal Disease Kidney Disease Kidney Disorder Renal Disorder Nephropathy Weight Loss
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