Semaglutide didn't significantly improve liver fibrosis or achieve resolution of NASH–related compensated cirrhosis compared with placebo, according to a phase 2 trial.
Loomba and colleagues conducted a double-blind, placebo-controlled phase 2 trial that enrolled 71 patients at 38 centers in the United States and Europe between June 2019 and April 2021. Adults with biopsy-confirmed NASH-related cirrhosis and a body mass index ≥ 27 were randomly assigned 2:1 to receive either once-weekly subcutaneous semaglutide at 2.4 mg or a visually matching placebo.
Among the 71 patients, 47 were randomly assigned to the semaglutide group and 24 to the placebo group. About 90% completed treatment, and 63 had evaluable paired biopsies for primary endpoint assessment. There also wasn't a significant difference between groups in the proportion of patients who achieved NASH resolution. In the semaglutide group, 16 patients had resolution compared with five patients in the placebo group .
Similar proportions of patients in each group reported adverse events. In the semaglutide group, 42 patients had an adverse event compared with 19 patients in the placebo group. In addition, six patients in the semaglutide group and two patients in the placebo group reported serious adverse events.
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