He should be well served by lessons from last year's turbulent case of David Bennett, the first patient at the University of Maryland to receive a genetically modified porcine heart.
The patient"is currently breathing on his own, and his heart is functioning well without any assistance from supportive devices," says the statement.
Despite a few setbacks, Faucette is"on the right track," said Muhammad M. Mohiuddin, MBBS, surgeon and xenotransplantation program director at the University of Maryland School of Medicine , in an interview. "We're taking one day at a time. His immune system is still intact, despite the heavy immune suppression," he told. His heart didn't carry a virus and"has not shown any signs of rejection so far."
The UMSOM team, Mohiuddin said,"is very hopeful that we will be able to at least mobilize the patient, and he can be discharged. But it's a little too early to call." Faucette, as part of his immunosuppressant regimen, is receiving tegoprubart , an experimental antibody that blocks CD40 ligand. His predecessor Bennett, in contrast, had received a blocker of the CD40 receptor along with other more familiar immunosuppressants., is in phase 1 studies looking at efficacy in patients with conventional kidney transplants.
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