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Penn State’s study reveals that early exposure to the chemical TCDF causes permanent changes to the gut microbiome in mice, increasing the risk of metabolic diseases later in life. This research underscores the potential human health impact of ‘forever chemicals’ and suggests possible microbiome-based treatments.
“POPs are pervasive in the environment and nearly every living organism has been exposed,” said Andrew Patterson, John T. and Paige S. Smith Professor of Molecular Toxicology and of Biochemistry and Molecular Biology, Penn State. “The negative health effects of these chemicals are well documented and include birth defects and cancer.
“We found that early life exposure to TCDF permanently disrupted the gut microbiomes of the wild-type mice,” said Yuan Tian, lead author and associate research professor, Penn State. “We also found that these mice had higher body weight and glucose intolerance at age four months.
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