Researchers from the Department of Biomedical Informatics have uncovered new insights into gene expressions associated with body mass index by tapping into a multiethnic cohort. The Department of Biomedical Informatics (DBMI) at the University of Colorado School of Medicine has uncovered 45 genes
The identification of both known and novel gene associations with body mass index offers a deeper understanding of the biology of obesity, as well as potential biomarkers and treatment targets.
Vargas, a CU School of Medicine Ph.D. student with an interest in personalized medicine, says these known and novel gene associations can provide insights into the biology of obesity, potential biomarkers, and therapeutic targets. The researchers analyzed RNA sequencing data from four self-identified race and ethnic groups in the MESA cohort – African American, Chinese American, Hispanic, and White – to assess the association of expression of each gene for an effect on BMI. Many of the characteristics related to cardiovascular risk are also relevant to obesity, making the MESA cohort ideal for obesity research.
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