Scientists reveal mechanism of maternal protein Pramel15 in promoting DNA demethylation in mouse zygotes

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Scientists reveal mechanism of maternal protein Pramel15 in promoting DNA demethylation in mouse zygotes
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DNA methyltransferase 1 (DNMT1) is an important DNA methyltransferase that maintains DNA methylation. The retention of DNMT1 and its cofactor UHRF1 in the cytoplasm is considered a major reason for passive DNA demethylation in the oocyte and early embryonic development.

Scientists reveal mechanism of maternal protein Pramel15 in promoting DNA demethylation in mouse zygotes retrieved 3 September 2024 from https://phys.org/news/2024-09-scientists-reveal-mechanism-maternal-protein.html

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