Research showed that LSD and psilocin (the primary molecule in magic mushrooms) bind to a specific receptor in the brains of laboratory mice, causing an antidepressant effect as a result.
of those patients don’t respond to traditional antidepressant medication either—resulting in treatment resistant disorders.
That poses a huge barrier for the vast majority of patients. However, if the drug was as easy as popping a pill at home without the worry of tripping out, then it could open the doors to treating millions of people. The study’s authors found that LSD and psilocin bind well to a receptor called TrkB in petri dishes. The binding resulted in an increase in neuroplastic activity. To study this mechanism further, the authors gave a single dose of LSD to mice with chronic stress. The team found that the drug resulted in an antidepressant effect due to the drug binding to TrkB.
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