Tissue-resident adult stem cells are the source of organ and tissue development, regeneration and maintenance. In many tissues they are also suspected as cancer cells-of-origin, both due to their long life-span as well as their self-renewal and regenerative capacities.
All mammals have mammary glands that produce milk, a feature that has fascinated scientists for many years. Questions such as why mammary glands evolved in the first place, how they have adapted across different species and what unique evolutionary pressures shaped their development remain largely unanswered.
While they are not exact miniature replicas of full-size organs, organoids contain enough cells and tissue architecture to recreate the environment and key functions of the organ they model. For example, a mammary gland organoid or a breast tissue organoid are composed of tiny elongated ducts that terminate in a spherical structure, mimicking the milk ducts and alveoli of the gland's tissue.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.My research focuses on generating mammary gland organoids from a variety of mammalian species. Mammals are incredibly diverse, with each species adapted to a wide range of environments and lifestyles. The mammary gland, essential for nurturing offspring, exhibits significant variation across species.
Insights beyond the mammary glandStudying the mammary gland's unique properties can also shed light on other areas of biology and medicine. Growing mammary gland organoids - YouTube Watch On Organoids also enable scientists to study the initiation, duration and cessation of lactation in different species. The process of lactation varies widely among mammals, influenced by factors such as hormonal changes and environmental conditions. Some mammals have unique forms of lactation.
They also reduce the ethical concerns associated with animal research. Organoids can be generated from animals that are not available for live research, such as rare or endangered species.—'Bionic breast' could restore sensation for cancer survivorsMoreover, organoids can be genetically modified to investigate specific genes and pathways, providing deeper insights into the molecular mechanisms underlying mammary gland biology.
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