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Before now, it was thought that only nerve endings in the skin and around the hair follicles could transmit the sensation.process to find that cells in part of the hair follicle called the outer root sheath had a higher percentage of touch-sensitive receptors than equivalent cells in the skin.
When the hair follicle cells were mechanically stimulated, the sensory nerves next to them were also activated – showing that touch had been registered.were being released by the ORS cells through tiny sacs called vesicles, as a way of signaling to the surrounding cells. "It's an exciting finding as it opens up so many more questions for these cells: why do they have this role, and what else can we learn from them about how our skin senses touch?". They're the reason we can feel everything from a light breeze to a firm press. In this case, the hair follicle cells were interacting specifically with low-threshold mechanoreceptors , capable of feeling gentle touches.
"This is a surprising finding as we don't yet know why hair follicle cells have this role in processing light touch,""Since the follicle contains many sensory nerve endings, we now want to determine if the hair follicle is activating specific types of sensory nerves for an unknown but unique mechanism."rather than hair follicle cells: in this case, histamine was released, but very little serotonin. That suggests something unique about what the ORS cells do.
"Our work uncovers a new role for skin cells in the release of histamine, with potential applications for eczema research,"
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