In a nationwide, multi-center clinical trial, scientists identified a promising new drug medication that improved liver fibrosis in NASH patients by 27%. Scientists from the University of California San Diego School of Medicine have led an investigation into a promising treatment for individuals wi
Scientists found that a drug, Pegozafermin, which mimics the body’s hormone, improved liver fibrosis and inflammation in NASH patients. Currently, there are no FDA-approved treatments for NASH, a common and often silent liver disease.
“Identifying an effective drug for NASH is extremely promising for patients as currently there are no FDA-approved therapies for this condition,” said Rohit Loomba, MD, the study’s first author and chief of the Division of Gastroenterology and Hepatology at UC San Diego School of Medicine. “NASH can adversely impact the quality of life in patients and can progress to cirrhosis. Its complications can lead to death or liver transplantation.
FGF21 controls energy use in the body and lipid metabolism in the liver. It has also been shown in previous studies to lower blood glucose and“The study’s results show that the new potential treatment not only improves fibrosis but also improves inflammation and liver injury along with significant improvements across multiple non-invasive biomarkers of NASH activity and scarring,” said Loomba, gastroenterologist, and hepatologist at UC San Diego Health.
Currently, there are no medications approved by the U.S. Food and Drug Administration available for the treatment of NASH, which is a type of nonalcoholic fatty liver disease ., approximately 24% of U.S. adults have NAFLD, and about 6% have NASH.
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