A new study identifies drug side effects across pediatric development stages. Pediatric drug side effects account for approximately 10% of pediatric hospitalizations, with nearly 50% of those being life-threatening. There is currently little evidence despite the need to learn more about these drugs
Evaluating drug safety in children is extremely difficult owing to growth and maturation processes that might change how children react to treatment.Pediatric drug side effects account for approximately 10% of pediatric hospitalizations, with nearly 50% of those being life-threatening. There is currently little evidence despite the need to learn more about these drugs and the negative effects they can have on children.
DBMI associate professor Nicholas Tatonetti and Nick Giangreco, a recent Systems Biology Ph.D. graduate at“For many reasons, children have historically not been included in clinical trials,” Tatonetti said. “There are many ethical issues around including children in trials, and there are several limitations when children are included that make it difficult to assess the effectiveness and safety of drugs.
The study goes beyond simply differentiating side effects in children from those in adults. It focuses on ADEs across seven developmental stages, starting at term neonatal and going through late adolescence, and it is powered by sharing information from neighboring developmental stages. For example, the development of infants and toddlers is close enough that there will be more shared characteristics than there would be for infants and those in early or late adolescence.
Giangreco, currently a Quantitative Translational Scientist at Regeneron, noted one of several side effects that were identified by this model. “This was a biologically-inspired modeling strategy,” Giangreco said. “We used what we knew about biological processes occurring during childhood and formed the modeling strategy. These safety signals came from this prior knowledge of the biological processes that are happening.
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