The clusters of lab-grown brain cells in brain organoids, which scientists use to study human brain development, differ from the cells in actual brains in some important ways, scientists report.
"We wanted to see whether the organoids that we and others have been using to model normal brain development as well as disease actually represented the cell types faithfully," he says
The organoids included the major cell types found in cortex. But the organoid cells were just a little off, says"In the normal brain you have very clear and precise different types of cells," she says."What we're seeing in the organoid is more of a confused identity." "Something about the artificial nature of the media or the conditions they're being grown in is actually resulting in this stress," saysWhen the team transplanted normal brain cells into a growing organoid, those cells became stressed and"this confused identity begins to arise," Andrews says.
Ming's lab has also detected stress in organoid cells. But she's not convinced that stress is the reason organoid cells remain immature and fail to acquire clear identities."That hasn't been established," she says.
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