There are many reasons to enjoy a cup of ruby red hibiscus tea, including its ability to warm the body in the winter, boost the immune system, regulate blood pressure, and aid in weight loss. Now, research has found that it could defeat Alzheimer's disease. Professor Kyong-Tai Kim and Ph.D. candi
Alzheimer’s disease is a progressive brain disorder that affects memory, thinking, and behavior. It is the most common cause of dementia in older adults and is characterized by the loss of neurons and synapses in the brain. Recent research has found that a compound in hibiscus has the potential to defeat Alzheimer’s.
AD begins as Aβ and Tau protein aggregates form deposits in the brain tissue. Microglia internalize such aggregates to protect the brain. However, incessant exposure to Aβ will ultimately exhaust the microglia, leading to a chronic inflammatory reaction and damage in the nerve cells. As a result, the victim suffers cognitive decline and memory loss.
Gossypetin administration and the subsequent changes in the brain tissue affected by Alzheimer’s disease. Credit: POSTECH sequencing. The analysis demonstrated that gossypetin prevented the expression of genes associated with gliosis, which promotes chronic inflammatory reactions while increasing the expression of genes associated with Aβ phagocytosis. In other words, gossypetin facilitated microglia’s Aβ clearance.
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