Scientists Discover Simple Way to Boost the Effectiveness of Popular Emergency Contraceptive Pill

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Scientists Discover Simple Way to Boost the Effectiveness of Popular Emergency Contraceptive Pill
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According to a randomized controlled trial recently published in The Lancet, combining the anti-inflammatory drug piroxicam, often prescribed for arthritis pain, with the levonorgestrel emergency contraceptive pill after unprotected intercourse results in fewer pregnancies compared to taking levonor

A recent study revealed that taking piroxicam with the levonorgestrel emergency contraceptive pill significantly prevents more pregnancies than levonorgestrel alone. The research found that 95% of pregnancies were prevented following combined treatment with levonorgestrel and the anti-inflammatory medication piroxicam, compared to 63% of pregnancies being prevented when levonorgestrel was taken alone.

“The levonorgestrel emergency contraceptive pill is one of the most popular choices of emergency contraception in many parts of the world, so finding out that there is a widely available medication that increases levonorgestrel’s efficacy when they are taken together is really exciting,” said Dr. Sue Lo from the Family Planning Association of Hong Kong, a co-investigator of the study.

Of the 836 women followed up, there was one pregnancy among the 418 women who took piroxicam and levonorgestrel and seven pregnancies among the 418 women who had the placebo and levonorgestrel. The percentage of expected pregnancies without contraception was estimated at 4.5% in both groups. Therefore, the percentage of pregnancies prevented following piroxicam-levonorgestrel co-treatment was 95% , compared with 63% in those who took levonorgestrel and placebo.

Professor Kristina Gemzell-Danielsson from the Karolinska Institute, another co-investigator, explained that “levonorgestrel prevents pregnancy by blocking or postponing the luteinizing hormone surge, which disrupts the ovulatory process. Piroxicam might work by targeting a different type of hormone – prostaglandins. Prostaglandins facilitate several reproductive processes including ovulation, fertilization, and embryo implantation.

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