Until recently, a definitive diagnosis of Alzheimer’s disease (AD) was once only possible after someone had died. However, contemporary biomarker studies have led to the development of imaging and spinal fluid tests for those still living. These tests can only monitor severe disease, differentiating
Researchers have identified a biomarker that could help physicians diagnose Alzheimer’s disease earlier, as a patient transitions into mild cognitive impairment.disease was once only possible after someone had died. However, contemporary biomarker studies have led to the development of imaging and spinal fluid tests for those still living. These tests can only monitor severe disease, differentiating advanced AD from related disorders.
Further experiments showed that p-tau198 was as effective as p-tau181 and p-tau217 in these assays. Importantly, both p-tau 198 and p-tau217 also could differentiate the brain tissue of patients with MCI — an early sign of AD — from older subjects without the impairment.
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