A new method to reprogram human cells to better mimic embryonic stem cells. In a groundbreaking study published on August 16 in the journal Nature, Australian scientists have resolved a long-standing problem in regenerative medicine. They developed a new method to reprogram human cells to better
Scientists have developed a revolutionary technique, termed “transient-naive-treatment reprogramming.” This method allows human cells to be reprogrammed to more closely resemble embryonic stem cells, addressing a longstanding issue in regenerative medicine. The team’s breakthrough promises to set new standards for cell therapies and research.
“However, a persistent problem with the conventional reprogramming process is that iPS cells can retain an epigenetic memory of their original somatic state, as well as other epigenetic abnormalities,” Professor Lister said. “This can create functional differences between the iPS cells and the ES cells they’re supposed to imitate, and specialized cells subsequently derived from them, which limits their use.
Dr. Sam Buckberry, a computational scientist from the Harry Perkins Institute, UWA, and Telethon Kids Institute, and co-first author of the study, said by studying how the somatic cell epigenome changed throughout the reprogramming process, they pinpointed when epigenetic aberrations emerged, and introduced a new epigenome reset step to avoid them and erase the memory.
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