Scientists Discover Chinmo – “The Youth Gene” — Researchers discover Chimn |
Absence of Chinmo in imaginal cells suppresses wing growth compared to control wing precursor tissue , while overexpression of the Chinmo gene induces tissue overgrowth, as occurs in processes tumors . Credit: IBE
Previous studies had discovered that the Br-C gene determines pupal formation in insects. In 2019, the same IBE team that has led this study described the essential function of E93 to complete metamorphosis in insects and initiate the maturation of the tissues that go on to form the adult. “We have discovered that Chinmo promotes tissue growth during the juvenile stage of Drosophila by keeping the cells undifferentiated. Thus, while Chinmo is expressed, cells cannot differentiate as the gene suppresses the action of those genes responsible for forming adult tissues,” says Dr. Xavier Franch, a researcher at the IBE who co-led the study.
“Understanding the molecular functioning of cell growth can help to better comprehend cancer processes. Healthy cells grow, differentiate, and mature. In contrast, cancer cells grow uncontrollably, do not differentiate, and fail to mature. So determining the role of Chinmo, Br-C, and E93 may be key to future clinical research,” says Dr. Jordi Casanova, an IRB Barcelona researcher and co-author of the study.
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