A research group have discovered a novel modulator for human regulatory T cells. This novel regulator can strengthen or dampen immune response and provides a new basis for therapeutic approaches for immune mediated diseases.
The research group of Professor Riitta Lahesmaa have discovered a novel modulator for human regulatory T cells. This novel regulator can strengthen or dampen immune response and provides a new basis for therapeutic approaches for immune mediated diseases. The Lahesmaa group is based at Turku Bioscience Centre of the University of Turku and Åbo Akademi University in Finland and is part of the InFLAMES Research Flagship.
The scientists at Turku Bioscience Centre have now discovered a novel RNA that controls the development and function of regulatory T cells. This long intergenic noncoding RNA modulates the levels of transcription factor FOXP3 and the suppressive function of human regulatory T cells by controlling the interleukin-2 receptor. The finding potentially enables the development of new therapeutic approaches to control the human immune response.
The discovery is particularly interesting because cancer cells are able to hide from the immune system by specifically manipulating regulatory T cells. Recently introduced immune activator therapeutic monoclonal antibodies for cancer are attempting to break this hiding process. Lahesmaa suggests that by targeting the novel lincRNA molecule, it may be possible to release immune activation in cancer without using expensive antibodies.
Alzheimer's, stroke, multiple sclerosis and other neurological diseases cause severe damage due to neuroinflammation mediated by immune cells. Managing this inflammation poses a significant medical ...
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