Science, Space and Technology News 2023
The hormone reduces appetite in animals and occurs at concentrations 100 times higher in pregnant women. Research from the University of Copenhagen has now discovered that it enhancesOver 500 million individuals globally are afflicted with diabetes, and approximately 2.6 billion people carry excess weight. A shared struggle for both cohorts is the suboptimal performance of insulin—a crucial hormone—in their bodies compared to those who are healthy and maintain a normal weight.
“Because quite high doses of GDF15 are needed to curb appetite, our lean rodents didn’t lose weight with the low doses that we gave them. However, their insulin sensitivity improved. It turned out that it was primarily their liver and fatty tissue that increased insulin sensitivity, and not the muscles, as we had anticipated,” says Richter.
One could be tempted to consider GDF15 as an inverse biomarker of general health – the lower the GDF15 while at rest, the better. But as with all of the other physiological conditions in which this mysterious hormone is in some way involved, the researchers still do not know exactly what role GDF15 plays:
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