Researchers from Purdue University have developed a novel cancer treatment that deceives cancer cells into absorbing a snippet of RNA that naturally blocks cell division. A study recently published in Oncogene reveals that over a 21-day period, tumors subjected to this treatment remained unchanged i
A new therapy targets cancer cells with a modified strand of micro-RNA that naturally blocks cell division. Credit: Second Bay Studios/Purdue Universityhave developed a novel cancer treatment that deceives cancer cells into absorbing a snippet ofreveals that over a 21-day period, tumors subjected to this treatment remained unchanged in size, whereas untreated tumors grew threefold.
In addition to slowing or reversing tumor growth, the targeted microRNA-34a strongly suppressed the activity of at least three genes – MET, CD44, and AXL – known to drive cancer and resistance to other cancer therapies, for at least 120 hours.
In healthy cells, microRNA-34a is abundant, but its presence is dramatically reduced in many cancer cells. As a bonus, the fully modified microRNA-34a is invisible to the immune system, which would ordinarily attack double-stranded RNA introduced to the body.
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