A team of researchers in China has achieved a scientific breakthrough by successfully creating mice with two fathers, marking a significant advancement in reproductive biology. This feat involved modifying imprinting genes, crucial for normal development, to ensure proper gene expression in the offspring.
A mouse with no biological mother has survived to adulthood in China – a major scientific achievement that's been years in the making.
That said, roughly half of their siblings failed to make it to adulthood, and nearly 90 percent of the viable embryos did not make it to birth, which means the success rate for the process can still be improved upon. When genetic material comes from two sperm, however, it can often result in a double silencing effect, whereby both copies of a gene are canceled out by mistake, leading to developmental disorders.
"Even when constructing bi-maternal or bi-paternal embryos artificially, they fail to develop properly, and they stall at some point during development due to these genes."mice with two mothers and no biological father for the first time way back in 2004, but reproduction without the need for sperm is easier to pull off than reproduction without the need for an egg.By contrast, there is no natural example of an animal with two fathers and no mother.
GENETICS REPRODUCTION STEM CELLS MOLECULAR BIOLOGY IMPRINTING GENES
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