For the first time, researchers have mapped the complex development of human skin in the womb using single-cell sequencing and spatial transcriptomics. This detailed atlas reveals how skin forms, hair follicles develop, and what goes wrong in certain skin diseases.
For the first time ever, scientists have charted the complex prenatal development of human skin, providing previously unobserved perspectives on skin morphology.
Professor Muzlifah Haniffa, co-lead author, said, “Our prenatal human skin atlas and organoid model provide the research community with freely available tools to study congenital skin diseases and explore regenerative medicine possibilities. A skin map of such microscopic detail could alter how we see and research congenital skin disorders. It could also potentially help develop treatments for conditions like blistering or scaly skin.
Through this organoid, the researchers were able to study how immune cells, specifically macrophages, contribute to blood vessel formation, or vascularization. It also provided insight into how the prenatal skin can heal without scarring.
Prenatal Development Skin Genomics Regenerative Medicine Congenital Diseases
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