Scientist behind Alzheimer’s drug candidate is indicted on charges of research fraud

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Scientist behind Alzheimer’s drug candidate is indicted on charges of research fraud
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Evan Bush is a science reporter for NBC News. He can be reached at [email protected].

A neuroscientist whose work helped pave the way for an Alzheimer’s drug candidate was indicted by a federal grand jury on Thursday on charges of fraud. The indictment, announced Friday by the Justice Department, brings additional scrutiny to the work of Hoau-Yan Wang, who has had multiple studies retracted and faced an investigation by the City University of New York, his employer, that was later halted.

investigation made “no conclusive findings of data manipulation, consistent with what I’ve been saying for two years.” Cassava said in a release on Friday that Wang had not participated in its most recent trial. In a news release, the company said: “Wang’s work under these grants was related to the early development phases of the Company’s drug candidate and diagnostic test and how these were intended to work.

had found evidence that the drug could affect signaling pathways with suspected involvement in Alzheimer’s. learned of the indictment on Friday, a spokesperson said in an email, adding: “The University has and will continue to cooperate to the fullest degree with the federal government’s investigation until the matter is resolved.” The indictment doesn’t specifically name the university, drug or company, listing them instead as “University 1,” “Drug A” and “Company 1,” respectively. Still, Cassava’s shares fell nearly 35% on Friday in a rapid plunge that triggered multiple trading halts.

that found evidence suggesting research misconduct. The university halted its investigation after Science published the report. Multiple journal articles on which Wang was an author have been retracted, according to the website Retraction Watch.

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