Researchers have found a way to use a simple, non-invasive scan to tell whether an experimental approach to enhance treatment for breast cancer is effective. The new research, led by scientists at The Institute of Cancer Research, London, could help doctors visualize tumors and speed up the development of targeted therapies for breast cancer.
," which consists of cells and fibers that provide a scaffold upon which the tumor can grow. This dense scaffold is known as the extracellular matrix and one of its key components is hyaluronic acid, a chemical that works by absorbing water.
To address this problem and help guide treatment, researchers performed MRI scans on mice with breast tumors to track the effects of PEGPH20, an experimentalThey used a scanning approach known as multiparametric MRI, which, as well as providing anatomical images, allows researchers to obtain other measurements that provide additional information about the tissue being analyzed.
PEGPH20 and other similar drugs targeting the dense ECM of breast cancer are experimental and will need to be tested in further clinical trials before entering the clinic.
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