A group of scientists has developed an entirely new approach to treating eating disorders. They showed that a group of nerve cells (so-called AgRP, agouti-related peptide neurons) in the hypothalamus control the release of endogenous lysophospholipids, which in turn control the excitability of ne
Scientists have discovered a brain circuit that controls food intake. By inhibiting this pathway, excessive food intake after fasting and obesity could be significantly reduced.They showed that a group of nerve cells in the hypothalamus control the release of endogenous lysophospholipids, which in turn control the excitability of nerve cells in the cerebral cortex, which stimulates food intake.
The research article “AgRP neurons control food intake behavior at cortical synapses via peripherally-derived lysophospholipids” has now been published in the journalNerve cells of a mouse brain and the protein PRG-1 . If the nerve cells contain PRG-1, the cells appear in yellow. Credit: Johannes Vogt
The team of researchers discovered an increased rate of obesity and the attendant type II diabetes in people with impaired synaptic LPA signaling. A group led by Professor Johannes Vogt , Professor Robert Nitsch and Professor Thomas Horvath has now shown that control of the excitability of neurons in the cerebral cortex by LPA plays an essential role in the control of eating behavior: AgRP neurons regulate the amount of lysophosphatidylcholine in the blood.
Johannes Vogt explained: “We saw a significant reduction in excessive food intake and obesity through gene mutation and pharmacological inhibition of ATX. Our fundamental findings on the LPA-controlled excitability of the brain, which we have worked on for years, therefore also play a central role for eating behavior.”
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