SARS-CoV-2 WA1/2020, Delta and Omicron strains found to infect human sensory neurons biorxivpreprint WhiteheadInst SARSCoV2 COVID19 Delta Omicron SensoryNeurons
By Pooja Toshniwal PahariaJan 13 2023Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 on the peripheral nervous system .
Sensory neurons of human origin were generated from iPS exposed to the SARS-CoV-2 WA1/2020 strain and variants of concern , such as the Delta variant and the Omicron variant. Single-cell ribonucleic acid sequencing was performed on HI SARS-CoV-2 or active WA1/2020. The team investigated whether the neurons could express ACE2 and acquire SARS-CoV-2 infection.
Results SARS-CoV-2 could infect 20% of the sensory neurons, with Omicron having the least infection rate . Even though the neurons were infected by SARS-CoV-2, the virus was unable to actively replicate and release viral progeny. After 1.50 months of differentiating human induced pluripotent stem cells into sensory-type of neurons, >90.0% of the cells showed sensory neuronal marker expression, including the receptor tyrosine kinase , tropomyosin receptor kinase B , peripherin 2 , Trk.
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