A study of ruxolitinib cream in patients with lichen planus indicated that the topical JAK inhibitor is a promising potential treatment for cutaneous lichen planus that is also well tolerated.
AMSTERDAM — Treatment with ruxolitinib cream, 1.5%, achieved rapid and marked reductions in the clinical signs and symptoms of cutaneous lichen planus , including itch and skin pain, both when given twice daily and as needed, according to data from a is a topical formulation of a Janus kinase 1/JAK2 inhibitor, approved by the US Food and Drug Administration for treating mild to moderate atopic dermatitis and for nonsegmental vitiligo in adults and children aged 12 years or older.
Consequently, “ruxolitinib cream represents a promising potential treatment for cutaneous lichen planus,” Mangold concluded. At week 16, significantly more patients treated with the ruxolitinib cream vs vehicle cream achieved IGA treatment success , defined as an IGA score of 0 or 1 with ≥ 2-grade improvement from baseline (odds ratio, 4.04;In the open-label extension, when all patients used the active cream as needed, the proportion achieving IGA treatment success increased to 60% among the patients originally treated with ruxolitinib cream and 60.9% among those who switched from the vehicle cream.
Otolaryngology ENT Specialty Head And Neck Surgery ENT Speciality Lichen Planus Pruritus Pruritis Itch Pain Management Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Blood Pain Washington Washington DC Washington - District Of Columbia Atopic Dermatitis Atopic Eczema
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