Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists have now demonstrated that this. RNAs are generally short-lived molecules that are constantly reconstructed to adjust to environmental conditions.
The research group hopes to decipher the complex aging process of the brain and gain a better understanding of related degenerative diseases.
Most cells in the human body are regularly renewed, thereby retaining their vitality. However, there are exceptions: the heart, the pancreas and the brain consist of cells that do not renew throughout the whole lifespan, and yet still have to remain in full working order."Aging neurons are an important risk factor for neurodegenerative illnesses such as Alzheimer's," says Prof. Dr.
In order to determine the life span of the RNA molecules, the Toda group worked together with the team from Prof. Dr. Martin Hetzer, a cell biologist at the Institute of Science and Technology Austria ."We succeeded in marking the RNAs with fluorescent molecules and tracking their lifespan in mice brain cells," explains Tomohisa Toda, who has unique expertise in epigenetics and neurobiology and who was awarded an ERC Consolidator Grant for his research in 2023.
"We are convinced that LL-RNAs play an important role in the long-term regulation of genome stability and therefore in the life-long conservation of nerve cells," explains Tomohisa Toda."Future research projects should give a deeper insight into the biophysical mechanisms behind the long-term conservation of LL-RNAs. We want to find out more about their biological function in chromatin regulation and what effect aging has on all these mechanisms.
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