RNAbindingproteins help Tcells pick their weapons before battle BabrahamInst NatureComms
Scanning electron micrograph of a human T lymphocyte from the immune system of a healthy donor. Credit: NIAID
Researchers from the Turner lab focused on the activity of the RNA binding proteins ZFP36 and ZFP36L1. By studying mice lacking these RNA binding proteins, the researchers were able to show that their absence in T cells during the initial phase of a viral infection leads to a superior cytotoxic immune response.
Their results were surprising, explains Dr. Georg Petkau, a postdoctoral researcher who led the work:"One striking observation of our study is that although the absence of RNA binding proteins in T cells results in stable accelerated differentiation and enhanced, this does not lead to signs of disease or tissue damage, which is often a logical consequence of overt cytotoxicity during an immune response.
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