Among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
Mar 22 2024American Association for Cancer Research Bottom line: Among patients over 65 who received an allogeneic hematopoietic stem cell transplant for the treatment of acute myeloid leukemia between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
Background: AML is typically treated with targeted therapies or intensive chemotherapy, but if those treatments fail, allo-HCT-;in which blood stem cells are taken from a matched donor and transplanted into a patient-;is often required. Historically, however, many patients over age 65 have been considered too infirm to receive intensive chemotherapy or allo-HCT.
Ali Bazarbachi, MD, PhD, senior author of the study and professor at the American University of Beirut Results: Relapse incidence decreased significantly from 37% to 31% to 30% across the three time periods; similarly, non-relapse mortality was 31% from 2000 to 2014 and decreased to 27% from 2015 to 2021.
Improvements in all outcomes except non-relapse mortality were observed regardless of whether patients were in their first complete response, second complete response, or had active disease at the time of transplant. For patients with active disease, however, these differences were only significant in the most recent time period . Decreases in non-relapse mortality were only observed for patients experiencing their second complete response.
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Study finds outcomes after stem cell transplant in elderly patients with AML have improved since 2000According to a study published in Clinical Cancer Research, among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
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